ChloroquineV1, France, Analysis, bibRecord, 000147

Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)

Identifieur interne : 000147 ( France/Analysis ); précédent : 000146; suivant : 000148

Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)

Auteurs : J. T. Banzouzi [France] ; P. Njomnang Soh [France] ; S. Ramos [France] ; P. Toto [France] ; A. Cave [France] ; J. Hemez [France] ; F. Benoit-Vical [France]

Source :

Journal of Ethnopharmacology [ 0378-8741 ] ; 2015.

RBID : Hal:hal-01925141

Abstract

Ethnopharmacological relevance: Uapaca paludosa is used in African traditional medicine for the treatment of malaria. Materials and methods: A bioguided fractionation of U. paludosa trunk bark extracts was performed on the basis of their antiplasmodial activity against Plasmodium falciparum. Results: A new natural betulin derivative named samvisterin (2) was isolated. In addition, 12 already known compounds were isolated from U. paludosa and tested against P. falciparum: squalene (1); lupeol (3), betulonic acid methyl ester (4), beta-sitosterol (5), stigmasterol (6), betulin (7), betulinic acid (8), pentadecanoic acid (9), palmitic acid (10), margaric acid (11), stearic acid (12), methyl palmitate (13). With the exception of betulinic acid, all were isolated for the first time from U. paludosa. Their chemical structures were established on the basis of spectroscopic analysis. The antiplasmodial activity of compounds 1-8 was confirmed on the chloroquine-resistant strain of P. falciparum, FcM29-Cameroon, with IC50 values ranging from 0.7 mu g/ml (for 1) to 30 mu g/mL (for 3). The cytotoxicity of the fractions and isolated compounds was also determined on KB and Vero cell lines in order to determine the cytotoxicity/activity ratio of each one. Conclusions: The results obtained with samvisterin (2) show that this new compound is the most promising of the series, with a weak cytotoxicity leading to the best selectivity index values. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Url:

https://hal.archives-ouvertes.fr/hal-01925141

DOI: 10.1016/j.jep.2015.07.023

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000212
to stream Hal, to step Curation: 000212
to stream Hal, to step Checkpoint: 000105
to stream Main, to step Merge: 000E59
to stream Main, to step Curation: 000E58
to stream Main, to step Exploration: 000E58
to stream France, to step Extraction: 000147

Links to Exploration step

Hal:hal-01925141

Le document en format XML

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          <orgName type="acronym">IRD</orgName>
          <desc>            <address>              <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
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<country>France</country>
</affiliation>
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</analytic>
<idno type="DOI">10.1016/j.jep.2015.07.023</idno>
<series><title level="j">Journal of Ethnopharmacology</title>
<idno type="ISSN">0378-8741</idno>
<imprint><date type="datePub">2015</date>
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<front><div type="abstract" xml:lang="en">              <p>Ethnopharmacological relevance: Uapaca paludosa is used in African traditional medicine for the treatment of malaria. Materials and methods: A bioguided fractionation of U. paludosa trunk bark extracts was performed on the basis of their antiplasmodial activity against Plasmodium falciparum. Results: A new natural betulin derivative named samvisterin (2) was isolated. In addition, 12 already known compounds were isolated from U. paludosa and tested against P. falciparum: squalene (1); lupeol (3), betulonic acid methyl ester (4), beta-sitosterol (5), stigmasterol (6), betulin (7), betulinic acid (8), pentadecanoic acid (9), palmitic acid (10), margaric acid (11), stearic acid (12), methyl palmitate (13). With the exception of betulinic acid, all were isolated for the first time from U. paludosa. Their chemical structures were established on the basis of spectroscopic analysis. The antiplasmodial activity of compounds 1-8 was confirmed on the chloroquine-resistant strain of P. falciparum, FcM29-Cameroon, with IC50 values ranging from 0.7 mu g/ml (for 1) to 30 mu g/mL (for 3). The cytotoxicity of the fractions and isolated compounds was also determined on KB and Vero cell lines in order to determine the cytotoxicity/activity ratio of each one. Conclusions: The results obtained with samvisterin (2) show that this new compound is the most promising of the series, with a weak cytotoxicity leading to the best selectivity index values. (C) 2015 Elsevier Ireland Ltd. All rights reserved.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
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<tree><country name="France"><noRegion><name sortKey="Banzouzi, J T" sort="Banzouzi, J T" uniqKey="Banzouzi J" first="J. T." last="Banzouzi">J. T. Banzouzi</name>
</noRegion>
<name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name>
<name sortKey="Cave, A" sort="Cave, A" uniqKey="Cave A" first="A." last="Cave">A. Cave</name>
<name sortKey="Hemez, J" sort="Hemez, J" uniqKey="Hemez J" first="J." last="Hemez">J. Hemez</name>
<name sortKey="Njomnang Soh, P" sort="Njomnang Soh, P" uniqKey="Njomnang Soh P" first="P." last="Njomnang Soh">P. Njomnang Soh</name>
<name sortKey="Ramos, S" sort="Ramos, S" uniqKey="Ramos S" first="S." last="Ramos">S. Ramos</name>
<name sortKey="Toto, P" sort="Toto, P" uniqKey="Toto P" first="P." last="Toto">P. Toto</name>
</country>
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</affiliations>
</record>

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   |wiki=    Sante
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   |texte=   Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)
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Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)

Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae)

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